The crash happened in the Middlesex County town of Westbrook at about 4:10 a.m. on Saturday, Jan. 7, Connecticut State Police reported.
A 2003 Ford Taurus was northbound on I-95 when it went off the road and struck the Exit 65 sign in the gore area, police said.
The car went airborne and landed overturned on the off-ramp.
The driver, identified as Ross Fielding, of Greenwich, Rhode Island, was taken to a hospital and was pronounced dead shortly before 6 a.m., State Police reported.
Police asked anyone with information about the crash to contact Trooper Barrera at 860-399-2100 or at daniel.barrera@ct.gov.
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